Selected Safety Information
- NEXPLANON should be removed if jaundice occurs.
- The NEXPLANON implant should be removed if blood pressure rises significantly and becomes uncontrolled.
How it works
Mechanism of action
The contraceptive effect of NEXPLANON is achieved by:
suppression of ovulation
increased viscosity of the cervical mucus
alterations in the endometrium
Selected Safety Information
About NEXPLANON (etonogestrel implant) 68 mg (continued)
- Studies suggest a small increased relative risk of developing gallbladder disease among combination hormonal contraceptive users. It is not known whether a similar risk exists with progestin-only methods like NEXPLANON.
- Prediabetic and diabetic women using NEXPLANON should be carefully monitored.
- Women with a history of depressed mood should be carefully observed. Consideration should be given to removing NEXPLANON in patients who become significantly depressed.
- In clinical trials with the non-radiopaque etonogestrel implant (IMPLANON), the etonogestrel levels in blood decreased below sensitivity of the assay by one week after removal of the implant. In addition, pregnancies were observed to occur as early as 7 to 14 days after removal. Therefore, a woman should re-start contraception immediately after removal of the implant if continued contraceptive protection is desired.
- Hormonal contraceptives may cause some degree of fluid retention. They should be prescribed with caution, and only with careful monitoring, in patients with conditions which might be aggravated by fluid retention. It is unknown if NEXPLANON causes fluid retention.
